The pharmaceutical industry requires sealing solutions of the highest standard — engineered not only for exceptional performance but also for full compliance with stringent regulatory requirements. From bottling to dosing applications, every seal must deliver proven resistance to a wide range of active pharmaceutical ingredients (APIs), diverse process media, and powerful cleaning agents, making seal selection a mission-critical decision.
Wherever fluids, solids, or gases are transferred or contained, sealing performance is defined by two critical factors: chemical resistance and the ability to consistently prevent contamination. At Chesterton Customseal, our medical-grade seals are manufactured to the highest regulatory standards and can be tailored in a variety of materials to suit even the most demanding pharmaceutical and medical applications.
Regulatory Confidence
All seals are designed and manufactured to meet the strictest industry standards, ensuring full compliance with global pharmaceutical regulations.
Exceptional Chemical Resistance
Engineered to withstand aggressive APIs, cleaning agents, and diverse process media without degradation, ensuring long-lasting performance.
Advanced Material Selection
Utilising premium elastomers and plastics, our seals deliver superior mechanical strength, durability, and resistance to contamination.
Customised Solutions
From complex geometries to specialised applications, our patented design capabilities enable us to create tailored sealing solutions that fit your exact requirements.
High-performance liquid chromatography (HPLC) is a chromatographic technique used to separate a mixture of compounds in analytical chemistry and biochemistry to identify, quantify, or purify the individual components of the mixture. HPLC is considered an instrumental technique of analytical chemistry (as opposed to a gravimetric technique). HPLC has many uses including medical (e.g. detecting vitamin D levels in blood serum), legal (e.g. detecting performance enhancement drugs in urine), research (e.g. separating the components of a complex biological sample, or of similar synthetic chemicals from each other), and manufacturing (e.g. during the production process of pharmaceutical and biological products).
The schematic of an HPLC instrument typically includes a sampler, pumps, and a detector. The sampler brings the sample mixture into the mobile phase stream which carries it into the column. The pumps deliver the desired flow and composition of the mobile phase through the column. The detector generates a signal proportional to the number of sample components emerging from the column, hence allowing for quantitative analysis of the sample components. A digital microprocessor and user software control the HPLC instrument and provide data analysis.
1) Solvent reservoirs, (2) Solvent degasser, (3) Gradient valve, (4) Mixing vessel for delivery of the mobile phase, (5) High-pressure pump, (6) Switching valve in “inject position”, (6′) Switching valve in “load position”, (7) Sample injection loop, (8) Pre-column (9) Analytical column, (10) Detector (i.e. IR, UV), (11) Data acquisition, (12) Waste or fraction collector.
The basic concept within the pump head is that the plungers are driven in and out by a motor. At the inlet & outlet ends of the pump, the head is a set of check valves. These valves only allow liquid to flow in one direction, from the mobile phase reservoir to the autosampler, column, and detector. One critical area within the set-up is the plunger seals, they play a crucial role in the overall system performance.
Four basic requirements of a plunger seal designer:
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